“One does not discover new lands without consenting to lose sight of the shore for a very long time.”
Who said it: Andre Gide, author and recipient of the Nobel Prize in Literature
“To lose sight” means your ability to see gets worse and worse. If you completely lose sight of something, as in this quote, it means you can’t see it any longer.
The phrase can also mean to become unfocused. For example, “He lost sight of the original plan” means that he has forgotten what he set out to do, and is now doing something else. In this situation, it has a negative meaning.
If you give your consent, then you agree to something. For example, “I gave my consent to hire him” means that you agreed to hire him.
So the quote above means you have to be ready to move forward even when you may not know what is going to happen. You have to leave behind what you know. This quote applies to business because if you want to “discover new lands” (do something that no one else has done yet; start a new business), you must leave “the shore” (the known). It may be scary at times, but in the end you will find or do something new, and it might be amazing!